Herein, we report an efficient phosphine-catalyzed sequential [4+1]/[2+3] annulation reaction of o-amino arylaldimines with Morita–Baylis–Hillman (MBH) carbonates. A wide range of hexahydropyrrolo[3,2-b]indoles bearing three consecutive stereogenic centers were obtained in 46–88% yields with all >20 : 1 d.r.
![Graphical abstract: Phosphine-catalyzed sequential [4+1]/[2+3] annulation of o-amino arylaldimines with Morita–Baylis–Hillman (MBH) carbonates](/en/Image/Get?imageInfo.ImageType=GA&imageInfo.ImageIdentifier.ManuscriptID=D6CC00562D&imageInfo.ImageIdentifier.Year=2026)
To support increased transparency, we offer authors the option to publish the peer review history alongside their article.
X. Hu, X. Qu, Z. Li, L. Wang, H. Yao, L. Li, Z. Cao, N. Huang and N. Wang, Chem. Commun., 2026, Advance Article , DOI: 10.1039/D6CC00562D
To request permission to reproduce material from this article, please go to the Copyright Clearance Center request page.
If you are an author contributing to an RSC publication, you do not need to request permission provided correct acknowledgement is given.
If you are the author of this article, you do not need to request permission to reproduce figures and diagrams provided correct acknowledgement is given. If you want to reproduce the whole article in a third-party publication (excluding your thesis/dissertation for which permission is not required) please go to the Copyright Clearance Center request page.
Read more about how to correctly acknowledge RSC content.
Please wait while we load your content...
