From the journal:

Chemical Communications

DHA/Fe2+-doped porphyrin COFs enable ROS-amplified multimodal tumor therapy

Qiaoqiao Sun,†a   Yuanhao Song,†a   Rongrong Liu,c   Wei Pan, ORCID logo a   Yanan Gao, ORCID logo *c   Yanhua Li,*a   Na Li ORCID logo a  and  Bo Tang ORCID logo ab  

* Corresponding authors

a College of Chemistry, Chemical Engineering and Materials Science, Key Laboratory of Molecular and Nano Probes, Ministry of Education, Collaborative Innovation Center of Functionalized Probes for Chemical Imaging in Universities of Shandong, Institute of Molecular and Nano Science, Shandong Normal University, Jinan, P. R. China
E-mail: liyanhua@sdnu.edu.cn

b Laoshan Laboratory, Qingdao 266237, P. R. China

c Key Laboratory of Advanced Materials of Tropical Island Resources, Ministry of Education, School of Chemistry and Chemical Engineering, Hainan University, Haikou 570228, China
E-mail: ygao@hainanu.edu.cn

Abstract

A porphyrin-based covalent organic framework system doped with Fe2+ and dihydroartemisinin (DHA) has been developed for enhanced antitumor therapy. This platform enables coordinated generation of reactive oxygen species (ROS) including DHA-derived radicals, Fe2+-driven chemodynamic therapy (CDT), and porphyrin-mediated photodynamic therapy (PDT), which collectively amplify oxidative stress and significantly improve therapeutic efficacy.

Graphical abstract: DHA/Fe2+-doped porphyrin COFs enable ROS-amplified multimodal tumor therapy

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Article information

DOI
https://doi.org/10.1039/D6CC00460A
Article type
Communication
Submitted
23 Jan 2026
Accepted
25 Feb 2026
First published
02 Mar 2026

Chem. Commun., 2026, Advance Article

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DHA/Fe2+-doped porphyrin COFs enable ROS-amplified multimodal tumor therapy

Q. Sun, Y. Song, R. Liu, W. Pan, Y. Gao, Y. Li, N. Li and B. Tang, Chem. Commun., 2026, Advance Article , DOI: 10.1039/D6CC00460A

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