A single heteroatom controls halogen- versus chalcogen-bond-driven cellular uptake

Abstract

Halogen and chalcogen bonds can both promote membrane recognition and here we demonstrate that within the same scaffold, oxygen analogues exhibit halogen-dependent uptake, whereas sulfur and selenium analogues rely mainly on chalcogen bonding.

Graphical abstract: A single heteroatom controls halogen- versus chalcogen-bond-driven cellular uptake

Supplementary files

Article information

Article type
Communication
Submitted
21 Jan 2026
Accepted
27 Feb 2026
First published
27 Feb 2026

Chem. Commun., 2026, Advance Article

A single heteroatom controls halogen- versus chalcogen-bond-driven cellular uptake

D. Giri, E. Chauhan and G. Mugesh, Chem. Commun., 2026, Advance Article , DOI: 10.1039/D6CC00396F

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