From the journal:

Chemical Communications

Bioinspired design of Ca2+-induced artificial signal transduction systems: ON/OFF emitting bacteria and excimer-FRET signalling-mediated bactericidal activity

Subrata Das,a   Raki Mandal, ORCID logo a   Rahul Prakash,a   Sandini P.,a   Sampurna Roya  and  Pradip Kumar Tarafdar ORCID logo *a  

* Corresponding authors

a Department of Chemical Sciences, Indian Institute of Science Education and Research Kolkata, Mohanpur, India
E-mail: tarafdar@iiserkol.ac.in

Abstract

Inspired by Ca2+-mediated loop clamping in proteins, we report an artificial signal transducer, PyLAD, featuring lithocholic acid linked to an aspartic acid moiety for Ca2+ recognition and a pyrene unit for signal-reporting, enabling horizontal signal transduction. Ca2+-induced assembly drives reversible ON/OFF signalling, cyan-emitting E. coli, and excimer-FRET signalling-induced inhibition of bacterial growth.

Graphical abstract: Bioinspired design of Ca2+-induced artificial signal transduction systems: ON/OFF emitting bacteria and excimer-FRET signalling-mediated bactericidal activity

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Article information

DOI
https://doi.org/10.1039/D6CC00258G
Article type
Communication
Submitted
27 Jan 2026
Accepted
24 Apr 2026
First published
27 Apr 2026

Chem. Commun., 2026, Advance Article

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Bioinspired design of Ca2+-induced artificial signal transduction systems: ON/OFF emitting bacteria and excimer-FRET signalling-mediated bactericidal activity

S. Das, R. Mandal, R. Prakash, S. P., S. Roy and P. K. Tarafdar, Chem. Commun., 2026, Advance Article , DOI: 10.1039/D6CC00258G

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