A one-pot, iodine-mediated, metal-free protocol has been developed for the synthesis of pyrazolo-fused pyridines from pyrazole amine, phenylglyoxal monohydrate, and phenylhydrazine hydrochloride. This method uses readily available substrates and offers a broad scope, and mechanistic studies reveal the role of iodine and the formation of 3 C–N and 2 C–C bonds.
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K. Perumal, M. Shanthi, V. Hemamalini, B. Shankar and S. Ramesh, Chem. Commun., 2026, Advance Article , DOI: 10.1039/D6CC00245E
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