From the journal:

Chemical Communications

A LEGO-inspired multipiece chip for portable nucleic acid detection

Ye Peng,†a   Lu Gao,†a   Pengkun Yin,a   Tianyu Dong,*ab   Ke Yi*c  and  Feng Li ORCID logo *a  

* Corresponding authors

a Key Laboratory of Green Chemistry & Technology of Ministry of Education, College of Chemistry, Sichuan University, Chengdu, Sichuan 610064, China
E-mail: dongielp3@163.com, windtalker_1205@scu.edu.cn

b Taihu Basin Monitoring Center of Hydrology and Water Resources, Wuxi 214024, China

c Department of Gynecology and Obstetrics, Key Laboratory of Obstetrics and Gynecologic and Pediatric Diseases and Birth Defects of Ministry of Education, West China Second Hospital, Sichuan University, Chengdu, Sichuan 610041, China
E-mail: yike@scu.edu.cn

Abstract

We report a LEGO-inspired multipiece chip (LIM-Chip), a modular microfluidic system capable of streamlining multiple nucleic acid amplification and detection steps through on-demand chip assembly via universal 3D-printed side release buckle connectors. The clinical applicability of the LIM-Chip is demonstrated by mediating a DNAzyme-based isothermal nucleic acid amplification assay for the sensitive detection of HPV16 DNA in clinical cervical samples.

Graphical abstract: A LEGO-inspired multipiece chip for portable nucleic acid detection

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Article information

DOI
https://doi.org/10.1039/D6CC00138F
Article type
Communication
Submitted
08 Jan 2026
Accepted
13 Feb 2026
First published
17 Feb 2026

Chem. Commun., 2026, Advance Article

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A LEGO-inspired multipiece chip for portable nucleic acid detection

Y. Peng, L. Gao, P. Yin, T. Dong, K. Yi and F. Li, Chem. Commun., 2026, Advance Article , DOI: 10.1039/D6CC00138F

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