From the journal:

Chemical Communications

Tumor microenvironment-responsive COF-based core–shell cascade nanoreactor with photocatalytic H2O2 self-supply for improved treatment

Wen-Xiu Ren,†a   Yue-Lu Tian,†a   You Li,a   Li-Li Tong,a   Qianqian Sun,b   Qing-Yun Huang,a   Jie Feng ORCID logo *a  and  Yu-Bin Dong ORCID logo a  

* Corresponding authors

a College of Chemistry, Chemical Engineering and Materials Science, Collaborative Innovation Center of Functionalized Probes for Chemical Imaging in Universities of Shandong, Key Laboratory of Molecular and Nano Probes, Ministry of Education, Shandong Normal University, Jinan, P. R. China
E-mail: jiefeng@sdnu.edu.cn

b Yantai Institute of Materia Medica, Yantai, Shandong, P. R. China

Abstract

A smart tumor-responsive core–shell nanoreactor (Cu@Hemin@COF@PDA) based on covalent organic frameworks (COFs) was designed. It enhances antitumor therapy through photocatalytic H2O2 self-supply, glutathione (GSH) depletion via Cu2+/Cu+ conversion, and integrated photothermal properties.

Graphical abstract: Tumor microenvironment-responsive COF-based core–shell cascade nanoreactor with photocatalytic H2O2 self-supply for improved treatment

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Article information

DOI
https://doi.org/10.1039/D5CC06338H
Article type
Communication
Submitted
07 Nov 2025
Accepted
02 Dec 2025
First published
02 Dec 2025

Chem. Commun., 2026, Advance Article

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Tumor microenvironment-responsive COF-based core–shell cascade nanoreactor with photocatalytic H2O2 self-supply for improved treatment

W. Ren, Y. Tian, Y. Li, L. Tong, Q. Sun, Q. Huang, J. Feng and Y. Dong, Chem. Commun., 2026, Advance Article , DOI: 10.1039/D5CC06338H

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