From the journal:

Chemical Communications

A clade-specific, amplification-free molecular lateral flow platform for on-site detection of Mpox

Satheesh Natarajan,ad   Ketan Dighe,b   David Skrodzki,b   Nandhakumar Ponnusamy ORCID logo a  and  Dipanjan Pan ORCID logo *abcde  

* Corresponding authors

a Department of Nuclear Engineering, The Pennsylvania State University, University Park, PA 16802, USA
E-mail: dipanjan@psu.edu

b Department of Biomedical Engineering, The Pennsylvania State University, University Park, PA 16802, USA

c Department of Materials Science and Engineering, The Pennsylvania State University, University Park, PA 16802, USA

d Huck Institutes of the Life Sciences, University Park, PA 16802, USA

e Department of Chemistry, Pennsylvania State University, University Park, PA, USA

Abstract

Development of a portable amplification-free lateral flow assay enables rapid Mpox clade-specific diagnostics, differentiating clades Ia, Ib, and II in 30 minutes with sensitivity of 102 copies µL−1 using ssDNA probes and gold nanoparticle readout).

Graphical abstract: A clade-specific, amplification-free molecular lateral flow platform for on-site detection of Mpox

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Article information

DOI
https://doi.org/10.1039/D5CC06114H
Article type
Communication
Submitted
27 Oct 2025
Accepted
12 Feb 2026
First published
13 Feb 2026

Chem. Commun., 2026, Advance Article

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A clade-specific, amplification-free molecular lateral flow platform for on-site detection of Mpox

S. Natarajan, K. Dighe, D. Skrodzki, N. Ponnusamy and D. Pan, Chem. Commun., 2026, Advance Article , DOI: 10.1039/D5CC06114H

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