Open Access Article
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Expression of concern: A multifunctional substance P-conjugated chitosan hydrochloride hydrogel accelerates full-thickness wound healing by enhancing synchronized vascularization, extracellular matrix deposition, and nerve regeneration
Hao
Li
a,
Mengna
Li
b,
Pei
Liu
a,
Kaiyang
Wang
a,
Haoyu
Fang
a,
Junhui
Yin
c,
Daoyu
Zhu
a,
Qianhao
Yang
a,
Junjie
Gao
ac,
Qinfei
Ke
b,
Hongping
Yu
*ad,
Yaping
Guo
*b,
Youshui
Gao
*a and
Changqing
Zhang
a
aDepartment of Orthopaedic Surgery, Shanghai Jiao Tong University Affiliated Sixth People's Hospital, Shanghai 200233, China. E-mail: yuhp09@126.com; gaoyoushui@sjtu.edu.cn
bThe Education Ministry Key Lab of Resource Chemistry and Shanghai Key Laboratory of Rare Earth Functional Materials, Shanghai Normal University, Shanghai 200234, China. E-mail: ypguo@shnu.edu.cn
cInstitute of Microsurgery on Extremities, Shanghai Jiao Tong University Affiliated Sixth People's Hospital, Shanghai 200233, China
dThe First Affiliated Hospital of Xiamen University, Xiamen 361005, China
First published on 23rd February 2026
Abstract
Expression of Concern for ‘A multifunctional substance P-conjugated chitosan hydrochloride hydrogel accelerates full-thickness wound healing by enhancing synchronized vascularization, extracellular matrix deposition, and nerve regeneration’, Hao Li et al., Biomater. Sci., 2021, 9, 4199–4210, https://doi.org/10.1039/D1BM00357G.
Biomaterials Science is publishing this expression of concern in order to alert our readers that we are presently unsure of the reliability of the data reported in Fig. 7a in the article.
The Royal Society of Chemistry has asked the affiliated institution (Shanghai Sixth People's Hospital, Shanghai Jiaotong University) to investigate this matter and confirm the integrity and reliability of the data in Fig. 7.
An expression of concern will continue to be associated with this manuscript until we receive information from the institution on this matter.
Signed: Maria Southall
Date: 1st December 2025
Executive Editor, Biomaterials Science
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