A conformation-dependent bifunctional fluorescent sensor for viscosity–pH monitoring in oxidative stress models

Abstract

A conformation-dependent bifunctional sensor is developed by capitalizing on a vibration-induced emission chromophore for viscosity sensing and an acid-triggered oxazolidine switch for pH sensing. This design yields a large Stokes shift (>150 nm), enabling dual-channel and crosstalk-free monitoring of viscosity and pH in oxidative stress models.

Graphical abstract: A conformation-dependent bifunctional fluorescent sensor for viscosity–pH monitoring in oxidative stress models

Supplementary files

Article information

Article type
Communication
Submitted
06 Nov 2025
Accepted
29 Dec 2025
First published
09 Jan 2026

Analyst, 2026, Advance Article

A conformation-dependent bifunctional fluorescent sensor for viscosity–pH monitoring in oxidative stress models

L. Guo, Y. Ding, H. Wu, Q. Long, Z. Zhang and J. Su, Analyst, 2026, Advance Article , DOI: 10.1039/D5AN01169H

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