Issue 13, 2025
From the journal:

Journal of Materials Chemistry B

In situ self-assembled peptide nanoparticles improve the anti-hepatic fibrosis effect†

Wenbin Liu,a   Beibei Wang,a   Mengxing Wei*bc  and  Zijuan Hai ORCID logo *a  

* Corresponding authors

a Institutes of Physical Science and Information Technology, Anhui University, Hefei, Anhui 230601, China
E-mail: zijuan@ahu.edu.cn

b Department of Radiology, the Second Affiliated Hospital of Anhui Medical University, Hefei, Anhui 230601, China

c Medical Imagine Research Center, Anhui Medical University, Hefei, Anhui 230601, China

Abstract

Antagonistic peptide Leu-Ser-Lys-Leu (LSKL) is capable of blocking the transforming growth factor-β1 (TGF-β1) signaling pathway and exhibits anti-fibrotic effects. Herein, we constructed LSKL nanoparticles (NPs) in situ based on an alkaline phosphatase (ALP)-instructed self-assembly strategy for improving its specific therapeutic effect against liver fibrosis.

Graphical abstract: In situ self-assembled peptide nanoparticles improve the anti-hepatic fibrosis effect

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Article information

DOI
https://doi.org/10.1039/D4TB02819H
Article type
Communication
Submitted
20 Dec 2024
Accepted
05 Mar 2025
First published
07 Mar 2025

J. Mater. Chem. B, 2025,13, 4080-4084

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In situ self-assembled peptide nanoparticles improve the anti-hepatic fibrosis effect

W. Liu, B. Wang, M. Wei and Z. Hai, J. Mater. Chem. B, 2025, 13, 4080 DOI: 10.1039/D4TB02819H

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