Self-disassembling supramolecular hydrogel from functionalized ultrashort peptides without external stimuli

Abstract

An ultrashort peptide-based supramolecular hydrogel exhibits a unique self-disassembling behaviour, driven by dynamic reorganization of its supramolecular architecture, transitioning from a kinetically entrapped fibrillar network to thermodynamically stable nanoparticle assemblies. Exploring such hydrogel systems provides insights into their underlying molecular mechanisms and unlocks potential avenues for materials applications.