Photoredox catalytic γ-C(sp3)–H vinylation of hydroxamic acid derivatives via 1,5-hydrogen atom transfer-mediated cross-dehydrogenative coupling

Abstract

A visible-light-induced regioselective γ-C(sp³)–H vinylation of hydroxamic acid derivatives with 2-aryl enamides was developed via cross-dehydrogenative coupling (CDC) reactions for the first time. This remote γ-vinylation was realized by the 1,5-hydrogen atom transfer (1,5-HAT) of amidyl radicals that were in situ generated through the photocatalytic N–O bond cleavage of hydroxamic acid derivatives.