Yongjiang
Yu
a,
Wang
Chen
a,
Rongrong
Hu
*a and
Ben Zhong
Tang
bc
aState Key Laboratory of Luminescent Materials and Devices, Guangdong Provincial Key Laboratory of Luminescence from Molecular Aggregates, South China University of Technology, Guangzhou 510640, China. E-mail: msrrhu@scut.edu.cn
bSchool of Science and Engineering, Shenzhen Institute of Aggregate Science and Technology, The Chinese University of Hong Kong, Shenzhen, Guangdong 518172, China
cAIE Institute, Guangzhou 510530, China
First published on 12th February 2025
Polythioureas are emerging materials with fascinating properties, such as self-healing and adhesion, high refractive indices, high dielectric constants, and heavy metal ion adsorption.With the increasing requirement for polymer structures and properties suiting a wide range of potential applications, versatile synthetic approaches are demanded to access a great diversity of polythiourea structures efficiently and economically. In this work, a commercially available difluorocarbene precursor, difluoromethylene phosphobetaine (PDFA), was selected to react with sulfur and electron-deficient aromatic amines to enable the efficient syntheses of electron-deficient polythioureas from amine monomers with low reactivity based on the high reactivity of a difluorothiocarbonyl intermediate. A one-pot catalyst-free multicomponent reaction of sulfur, PDFA and an amine was designed, which could take place efficiently in DMAc at 60 °C under nitrogen and was applicable for aromatic amines with both electron-donating and electron-withdrawing groups, producing thioureas in high yields (up to 93%). Most importantly, catalyst-free multicomponent polymerizations of sulfur, PDFA, and diamines were also developed in DMAc at 60 °C with commercially available monomers, showing high efficiency (Mws up to 65900 g mol−1 and yields up to 99%) and wide monomer applicability, providing an efficient synthetic approach for syntheses of polythioureas. Moreover, these polythiourea thin films showed high refractive indices (n633 nm up to 1.8133), suggesting their potential application in optical devices.
The commonly adopted synthetic approaches for polythioureas have mainly been divided into two kinds. One is polycondensations between diamine monomers and thiophosgene,7 diimidazolethiocarbonyl,1 or thiourea.12 These sulfur-containing reagents are generally toxic and smelly, difficult to handle, release harmful small molecules, and some even required special synthetic conditions, such as microwave assistance. The other method is polyadditions between diisothiocyanates and diamine monomers.13 While the reaction is efficient, the diisothiocyanate monomers were difficult to synthesize, and there was only limited commercially available diisocyanate compound. Recently, carbon disulfide was utilized for the synthesis of polythioureas;14,15 however, an equivalent amount of sulfur-containing small molecules such as H2S would be released as a byproduct, which was environmentally unfriendly. The limitations of the sulfur-containing monomers have vastly hindered the exploration of the chemical structures of polythioureas.
Elemental sulfur, which abundantly exists in nature, is one of the major byproducts of the petroleum and natural gas industries,16–19 and is a non-toxic, safe, odorless solid powder. It could serve as an ideal and economical monomer for the synthesis of sulfur-containing polymers. Great efforts have been made to utilize elemental sulfur to prepare polymeric materials, such as inverse vulcanization to synthesize chalcogenide hybrid inorganic/organic polymers.20–24 Polymerizations of sulfur were also reported for the synthesis of poly(benzothiazole)s,16 polydisulfides,25 poly(O-thiocarbamate)s,26 polythioamides27,28 and others. Among various sulfur-utilization approaches, multicomponent polymerization (MCP), with three or more monomers reacting together in a one-pot procedure to afford the targeted polymeric product,29–33 offers an efficient approach to convert elemental sulfur to various sulfur-containing polymers, such as polythioamides,34,35 polythiocarbamates,26 and polythioureas.11 Additionally, it has shown fascinating advantages, including high efficiency, simple operation, mild conditions, robustness, and, most importantly, great polymer product structural diversity. We have reported the MCPs of elemental sulfur, aliphatic diamines, and diisocyanates to afford polythioureas with various aliphatic or semi-aromatic structures.11,22,27 The MCPs of elemental sulfur, CH2Cl2 and aromatic diamines were also recently developed to afford a series of aromatic polythioureas with high efficiency.36 MCPs of sulfur, chloroform and aromatic diamines were also reported to produce polythioureas with several repeating unit structures through the use of dichlorocarbene active species in the presence of a large amount of the strong base t-BuOK.37 However, for aromatic amines with electron-withdrawing groups, which exhibit lower reactivity and weaker nucleophilicity compared to those with electron-donating groups, it was challenging to realize efficient transformations to thioureas. It is hence still difficult to access electron-deficient aromatic polythioureas, which are required and highly desired for potential applications in organic catalysis38 and for other optical and electronic applications.39
To react efficiently with the less-reactive aromatic diamines, difluorocarbene as an active reaction intermediate could be a promising candidate; it was commonly used for fluoromethylations,40–43 insertion reactions of X–H bonds (X = O, N, S), and [2 + 1] cycloaddition reactions involving multiple bonds.44 Xiao et al. developed a difluoromethylene phosphobetaine (PDFA) reagent to produce difluorocarbene in situ to further participate in N-trifluoromethylation,45C-trifluoromethylthiolation,46,47etc. In these reactions, PDFA was reported to react with sulfur to generate thiocarbonyl fluoride in situ, which then reacted with various amines to afford trifluoromethylated products, isothiocyanates, and HCF2S-substituted heterocycles.45 For example, PDFA, sulfur and an aromatic amine could react in 1,2-dimethoxyethane at 80 °C to afford the isothiocyanate in 85% yield, which could further react with dimethylamine to produce thiourea-containing chloromethiuron; additionally, a vicinal diamine with two neighboring –NH2 groups on a benzene ring was reported to react with PDFA and sulfur to afford cyclic thiourea in 75% yield at 80 °C in 1,2-dimethoxylethane (DME). The highly reactive difluorothiocarbonyl intermediate could hence undergo nucleophilic attack reactions with amines, including less-reactive electron-withdrawing-group-containing aromatic amines, to afford the corresponding polythioureas under suitable reaction conditions (Fig. 1).
![]() | ||
Fig. 1 A strategy for polythioureas synthesized from diamines containing electron-withdrawing groups. |
In this work, to develop a polymerization approach for the synthesis of polythioureas, the one-pot multicomponent reaction of PDFA, sulfur, and two amine molecules was first investigated to directly produce a thiourea product. As solvents such as DME were not favored for the solubility of polythioureas with abundant intermolecular hydrogen bonds and strong polarity, polar solvents such as dimethylacetamide (DMAc) were adopted. Moreover, utilizing the highly reactive thiocarbonyl fluoride generated from PDFA and sulfur, electron-deficient aromatic amines might react efficiently to produce thiourea from sulfur. Herein, one-pot catalyst-free multicomponent reactions of sulfur, PDFA and electron-withdrawing-group-containing aromatic amines were reported to afford thiourea products in high yields. Efficient and rapid polymerizations of sulfur, PDFA and various aromatic and benzyl diamines were developed without any catalyst under mild conditions, producing a series of polythioureas with high yields and high Mws of up to 65900 g mol−1. In particular, aromatic polythioureas with electron-withdrawing carbonyl groups were successfully prepared in 85% yield and with a Mw of 18
600 g mol−1, and they proved to possess the highest refractive index of 1.8133 at 633 nm among the tested aromatic polythioureas.
Entry | [1a]![]() ![]() ![]() ![]() |
Solvent | T (°C) | Yielda (%) |
---|---|---|---|---|
The reaction was carried out under nitrogen conditions at the corresponding temperature with 1 mL of solvent; the concentration of 1a was 1.0 M, and the reaction time was 0.5 h.a Calculated based on 1H NMR spectra, using 1,3,5-trimethylbenzene as the internal standard.b Isolated yield. | ||||
1 | 2![]() ![]() ![]() ![]() |
DME | 50 | 64 |
2 | 2![]() ![]() ![]() ![]() |
THF | 50 | 67 |
3 | 2![]() ![]() ![]() ![]() |
DMSO | 50 | 54 |
4 | 2![]() ![]() ![]() ![]() |
DMF | 50 | 72 |
5 | 2![]() ![]() ![]() ![]() |
DMAc | 50 | 80 |
6 | 2![]() ![]() ![]() ![]() |
DMAc | 60 | 83 |
7 | 2![]() ![]() ![]() ![]() |
DMAc | 70 | 82 |
8 | 2![]() ![]() ![]() ![]() |
DMAc | 80 | 82 |
9 | 2![]() ![]() ![]() ![]() |
DMAc | 60 | 87 |
10 | 2![]() ![]() ![]() ![]() |
DMAc | 60 | 94 (91)b |
11 | 2![]() ![]() ![]() ![]() |
DMAc | 60 | 88 |
12 | 2![]() ![]() ![]() ![]() |
DMAc | 60 | 90 |
With the high efficiency of the catalyst-free MCR, the monomer scope of amines was then studied, and a series of commercially available electron-withdrawing-group-containing aromatic amines 1a–1g was selected to react with sulfur and PDFA in DMAc at 60 °C for 0.5 h (Fig. 2). Under the optimized conditions, these electron-deficient aromatic amines generally reacted efficiently, affording the corresponding thiourea products 4a–4g in high yields. Aromatic amines with benzoyl, ester, –NO2, and sulfonyl groups generally worked well in the MCR, producing rarely reported aromatic thiourea structures in 84–90% isolated yields, demonstrating the good structural tolerance of the MCR. 3-Cyanoaniline 1e showed a lower yield, probably because of a side reaction involving the –CN group. Besides these electron-deficient aromatic amines, p-toluidine 1h with an electron-donating methyl group could also react efficiently under the same conditions, affording the thiourea 4h in 93% yield, showing a similarly high yield to the electron-deficient aromatic amines. Moreover, in addition to aromatic amines, the benzylamine 1i was also investigated, and the MCR of sulfur, PDFA and 1i also proceeded smoothly to afford the thiourea 4i in 62% yield. The catalyst-free MCR hence exhibited a broad amine substrate scope, accommodating electron-deficient and electron-rich aromatic amines as well as aliphatic amine, suggesting its robustness and wide applicability.
![]() | ||
Fig. 2 MCRs of sulfur, PDFA and aromatic amines to form thioureas; the single-crystal-based ORTEP diagrams of compounds 4d–4i are given. |
During the catalyst-free MCR of p-toluidine 1h, sulfur and PDFA in DMAc, after reacting at 60 °C for 20 min, the reaction solution was cooled in an ice bath and the mixture was filtered for high-resolution mass spectrometry (HRMS) analysis. The characteristic peaks of thiocarbonyl fluoride (found 82.9770, calcd 82.9767) and isothiocyanate (found 150.0374, calcd 150.0377) were observed, indicating the key intermediates involved in the reaction mechanism (Fig. S1†). In this MCR, the difluorocarbene active species A was generated from PDFA upon heating, with the release of Ph3PS and CO2; A then reacted with sulfur to produce thiocarbonyl fluoride B according to the literature.45 The nucleophilic substitution of the amine then took place to afford the intermediate C, and after F− was eliminated, the isothiocyanate intermediate D was generated, which then underwent nucleophilic addition with another amine molecule to afford the thiourea product E (Fig. S2†).
Moreover, several single crystals of these thiourea compounds, including unreported thiourea compounds, were obtained via solvent evaporation or diffusion. The thioureas containing –CF3, –CN, –NO2, and sulfonyl groups, 4d–4g, generally adopted “W”-shaped molecular configurations in their single crystal structures (Fig. 2). For example, in the single crystal structure of the NO2-containing thiourea 4f, two THF solvent molecules were captured through N–H⋯O hydrogen bonds. The –NO2 groups also contributed to the formation of rich hydrogen bond networks in the crystal structure (Fig. S3†). Different from that, the single crystal of the CH3-containing thiourea 4h was monoclinic with a space group of Pbcn, adopting a “V”-shaped molecular conformation, which was the same as reported crystals prepared via other synthetic approaches.48 A dense hydrogen bond network was formed through –N–H⋯S bonds with a length of 2.496 Å (Fig. S3†). Different from the two above-mentioned types of thioureas, 4i prepared from a benzylamine possessed an asymmetric conformation. Different types of thiourea structures hence adopted different molecular conformations because the hybridization of C–N bonds imparts cis–trans isomeric properties on the C–N bonds of the thiourea moiety, influencing the spatial arrangement of associated N–H bonds. The presence of multiple and diverse hydrogen bonds endows the polythioureas with various hydrogen bond networks.
Entry | T (°C) | [5a]![]() ![]() ![]() ![]() |
M
w![]() |
M w/Mn | Yield (%) |
---|---|---|---|---|---|
a The substrate 5a (1.0 mmol) was combined with Ph3P+CF2CO2− and S8 in 1 mL of DMAc and the mixture was stirred for 3 h at the corresponding temperature under N2. b The data were obtained from GPC testing in DMF, with monodisperse PMMA as the standard sample. | |||||
1 | 40 | 1.0![]() ![]() ![]() ![]() |
16![]() |
1.34 | 84 |
2 | 50 | 1.0![]() ![]() ![]() ![]() |
20![]() |
1.26 | 82 |
3 | 60 | 1.0![]() ![]() ![]() ![]() |
53![]() |
1.82 | 94 |
4 | 70 | 1.0![]() ![]() ![]() ![]() |
36![]() |
1.51 | 98 |
5 | 80 | 1.0![]() ![]() ![]() ![]() |
31![]() |
1.50 | 93 |
6 | 60 | 1.0![]() ![]() ![]() ![]() |
13![]() |
1.24 | 65 |
7 | 60 | 1.0![]() ![]() ![]() ![]() |
22![]() |
1.35 | 79 |
8 | 60 | 1.0![]() ![]() ![]() ![]() |
37![]() |
1.73 | 97 |
9 | 60 | 1.0![]() ![]() ![]() ![]() |
18![]() |
1.47 | 88 |
10 | 60 | 1.0![]() ![]() ![]() ![]() |
49![]() |
1.73 | 90 |
11 | 60 | 1.0![]() ![]() ![]() ![]() |
51![]() |
1.77 | 94 |
Surprisingly, unlike other sulfur- and aromatic-amine-based polymerizations, the addition of base was not necessary or even beneficial to the MCP, and the incorporation of K2CO3, Na2CO3, NaOH, KF, or triethylamine did not improve the polymerization results (Table S2†), suggesting that simple base-free conditions were optimal, probably due to the reduction of base-promoted side reactions such as the generation of trifluoromethylthio-containing byproducts.42 The progression of the MCP over time was also investigated; it could afford the polymer product with a Mw of 42000 g mol−1 in 87% yield within 10 min, reaching 65
900 g mol−1 in 93% yield after 1 h, suggesting fast and efficient polymerization (Table S3†). Last but not least, the influence of the concentration of the monomer 5a was then investigated while fixing the monomer feed ratio. A low concentration of 0.25 M resulted in relatively low Mws, while the monomer could not be completely dissolved at a high concentration of 1.0 M; 0.5 M was found to be the optimal concentration (Table S4†).
To explore the monomer scope of the catalyst-free MCP, a series of commercially available diamines 5a–5h was selected to be used as the monomers; these were polymerized with sulfur and PDFA under the optimal conditions in DMAc at 60 °C under nitrogen (Fig. 4 and Fig. S6†). Polythiourea P1 with a high Mw of 65900 g mol−1 was obtained in 93% yield, and good polymerization results were also obtained for the ether- and thioether-containing polythioureas P2 and P3. While these aromatic polythioureas could generally be dissolved in DMF, DMSO, and DMAc, P4 and P5 showed limited solubility; during their synthesis, large amounts of insoluble precipitate were formed, and only the soluble part was used for characterization. The diamine 5f with large steric hindrance might twist the polymer chain and avoid strong interchain stacking, which might produce a polythiourea with improved solubility, while sacrificing yield. Furthermore, the MCPs of aliphatic diamines were not as efficient as those with aromatic diamines, and polythioureas P7 and P8 possessed decreased yields and Mws. The polydispersity of the molecular weights of these polymers was generally low for a step-growth polymerization approach, which was probably associated with the special solubility of these polythioureas.
Most importantly, considering challenging electron-withdrawing-group-containing aromatic amine monomers, the sulfonyl- and carbonyl-group-containing electron-deficient aromatic diamines 5i and 5j were studied in the catalyst-free MCP (Fig. 5), and they were polymerized with sulfur and PDFA in DMAc at 60 °C for 1 h. The electron-deficient aromatic polythioureas P9 and P10 were obtained in 76% and 85% yields, respectively, with Mws of 7900 g mol−1 (P9) and 18600 g mol−1 (P10). These rarely reported results suggested the successful polymerization of electron-deficient aromatic diamine monomers.
![]() | ||
Fig. 5 MCPs of the electron-withdrawing-group-containing diamines 5i–5j. Mws are determined using GPC in DMF based on a PMMA standard sample. |
Most of the polymers possess satisfying solubility, enabling facile thin film preparation via a spin-coating method. The wavelength-dependent refractive indices of thin films of P1–P3, P6–P7, and P9–P10 were measured within the wavelength range of 400–1700 nm (Fig. 7B). The aromatic polythioureas generally showed higher refractive indices compared with the polythiourea P7 prepared from 1,4-bis(aminomethyl)benzene; and P10 with electron-withdrawing carbonyl groups possessed the highest n633 nm value of 1.8133, which was exceptionally high for organic polymer materials (Table S5†). Moreover, several polymers possessed high n values above 1.7 at 1700 nm, which have rarely been reported. The transmittance spectra of these polymers were also investigated, and their spin-coated thin films on quartz plates were measured. As shown in Fig. S16,† among the tested polythiourea samples of uniform thin films on quartz plates, P1, P2, and P10 showed excellent light transmittance of above 96% beyond 400 nm. Photos of solid samples and thin films on quartz plates of P10 also suggested its high transmittance. These aromatic polythioureas, especially P10 with electron-withdrawing groups, possessed excellent optical properties, and they could be promising optical materials for optical lenses and CMOS systems.
Footnote |
† Electronic supplementary information (ESI) available. CCDC 2407294–2407296, 2407300, 2407301, 2245406. For ESI and crystallographic data in CIF or other electronic format see DOI: https://doi.org/10.1039/d4py01387e |
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