Selective electrochemical trifluoromethylation of arylamide- or aryl-substituted pyrrole derivatives

Abstract

A selective electrochemical trifluoromethylation reaction for pyrroles, particularly those containing additional aryl groups, has been developed for the synthesis of 2-trifluoromethylpyrrole derivatives. The cost-effective CF₃SO₂Na has been employed in the electrochemical trifluoromethylation of pyrroles using an undivided electrolytic cell under transition-metal-free conditions. This approach demonstrates that arylamide-substituted or aryl-substituted pyrrole derivatives exhibit favorable regioselectivity and site selectivity under electrochemical oxidation conditions. Additionally, this study contributes to the ongoing development and understanding of electrochemical trifluoromethylation methodologies.