Facile access to multi-substituted trifluoromethyl alkenes via dehydroxyfluorination of 3,3-difluoroallyl alcohols

Abstract

The dehydroxyfluorination of allylic alcohols stands as one of the most direct and effective methods for synthesizing versatile allylic fluorides. However, regioselectivity control in this transformation remains challenging. Herein, we demonstrate a fluorine effect-induced regiospecific dehydroxyfluorination of 3,3-difluoroallyl alcohols using Olah's reagent under mild reaction conditions.