Recent developments in nitroxide-mediated aerobic oxidations

Abstract

Alcohol oxidations are prevalent reactions in organic synthesis, at both industrial and laboratory scales. Nitroxyl radicals constitute a versatile class of reagents, finding extensive use as catalysts for the oxidation of organic molecules. The development of novel, versatile methodologies holds promise to enhance the efficiency of synthetic strategies relying on class-selective oxidation. This review mainly describes the scope of nitroxyl radical-catalyzed alcohol aerobic oxidations, focusing on systems characterized by high activity, selectivity, and operational stability. Future advancements in this field hold promise to pave the way for novel opportunities to enhance the efficiency of organic synthesis.