Multicomponent reaction (MCR): An emerging tool-box of protein bioconjugation

Abstract

Bioconjugation of protein is a powerful process that has tremendous application in the fields of material sciences and medicine industries. Multicomonent reactions (MCRs) provide an opportunity to conjugate at least two important molecules with protein and furnish a versatile bioconjugate. In last decade, bioconjugation chemistry has got a remarkable momentum with the involvement of different MCRs. Several MCRs have been already utilized to furnish valuable bioconjugates. Unfortunately, a systematic review that describes this methodological development of protein bioconjugation utilizing MCR is still very rare. Thus, in this review, we wish to showcase the methodological progress of the bioconjugation of proteins employing different MCRs with an emphasis of their postulated mechanisms. The article also highlights the wealth of untapped opportunities in the fields of analytical and medicinal chemistry including development of vaccines and antibody drug conjugates.