Issue 30, 2025

Asymmetric synthesis and biological evaluation of ottensinin and its analogues

Abstract

The asymmetric synthesis of ottensinin, a rearranged labdane diterpene with a broad range of favourable bioactivities, has been realized based on fragment coupling of 16a and 13 in eight steps from (+)-sclareolide. This approach would enable the diverse synthesis of ottensinin analogues to facilitate future drug development based on ottensinin.

Graphical abstract: Asymmetric synthesis and biological evaluation of ottensinin and its analogues

Supplementary files

Article information

Article type
Communication
Submitted
23 Jun 2025
Accepted
09 Jul 2025
First published
10 Jul 2025

Org. Biomol. Chem., 2025,23, 7120-7123

Asymmetric synthesis and biological evaluation of ottensinin and its analogues

J. Liang, Z. Xu, Y. Xie, W. Chen, Y. He and Y. Hu, Org. Biomol. Chem., 2025, 23, 7120 DOI: 10.1039/D5OB01028D

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