From the journal:

Organic & Biomolecular Chemistry

Tf2O-activated modular assembly of tetrasubstituted alkenes

Weijian Ye,a   Yuqi Chen,a   Xiangning Liu,a   Yiran Huang,a   Yuanyuan Zhanga  and  Xiaobing Wan ORCID logo *a  

* Corresponding authors

a Key Laboratory of Organic Synthesis of Jiangsu Province, College of Chemistry, Chemical Engineering and Materials Science, Soochow University, Suzhou 215123, China
E-mail: wanxb@suda.edu.cn

Abstract

A novel, efficient multicomponent strategy for constructing tetrasubstituted alkenes bearing both C(sp2)–S and C(sp2)–N bonds has been developed, utilizing Tf2O-mediated activation of 1,3-diketones and featuring high stereoselectivity and broad substrate compatibility.

Graphical abstract: Tf2O-activated modular assembly of tetrasubstituted alkenes

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Article information

DOI
https://doi.org/10.1039/D5OB00951K
Article type
Communication
Submitted
10 Jun 2025
Accepted
15 Aug 2025
First published
16 Aug 2025

Org. Biomol. Chem., 2025, Advance Article

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Tf2O-activated modular assembly of tetrasubstituted alkenes

W. Ye, Y. Chen, X. Liu, Y. Huang, Y. Zhang and X. Wan, Org. Biomol. Chem., 2025, Advance Article , DOI: 10.1039/D5OB00951K

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