Transition-metal-free K2S2O8-promoted oxidative C–C triple bond cleavage and esterification leading to α-ketoesters

Jin-Xin Lan; Yu Shu; Yang Zhou; Liu-Yu Shen; Fei Meng; Wen-Chao Yang

doi:10.1039/D5OB00892A

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Transition-metal-free K₂S₂O₈-promoted oxidative C–C triple bond cleavage and esterification leading to α-ketoesters†

Jin-Xin Lan,^a Yu Shu,^a Yang Zhou,^a Liu-Yu Shen,^a Fei Meng^a and Wen-Chao Yang

*^a

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* Corresponding authors

^a School of Plant Protection, Yangzhou University, Yangzhou 225009, P. R. China
E-mail: wccyang@126.com

Abstract

A sustainable method for converting alkynes into α-ketoesters is reported through K₂S₂O₈-promoted oxidative C–C triple bond cleavage and esterification. This approach avoids transition metal catalysis, photocatalysts, and pure oxygen conditions, making it both efficient and more convenient.

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Article information

DOI: https://doi.org/10.1039/D5OB00892A
Article type: Paper
Submitted: 28 May 2025
Accepted: 25 Jun 2025
First published: 26 Jun 2025

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Org. Biomol. Chem., 2025, Advance Article

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Transition-metal-free K₂S₂O₈-promoted oxidative C–C triple bond cleavage and esterification leading to α-ketoesters

J. Lan, Y. Shu, Y. Zhou, L. Shen, F. Meng and W. Yang, Org. Biomol. Chem., 2025, Advance Article , DOI: 10.1039/D5OB00892A

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Organic & Biomolecular Chemistry