Cytotoxic polyketides from the desert soil-derived fungus Preussia fleischhakii H231

Abstract

Three new heterodimeric polyketides, fleisine A–C (1–3), were obtained from the fermentation product of the desert soil-derived fungus Preussia fleischhakii H231. The structures of 1–3 were elucidated through an integrated analysis of spectroscopic data, while the absolute configurations were established by chemical hydrolysis followed by calculated electronic circular dichroism (ECD). Biological evaluation revealed that compounds 1 and 2 exhibited potent cytotoxicity against multiple human tumor cell lines. The IC₅₀ values ranged between 2.3 and 25.2 μM. Further in vitro assays demonstrated that compounds 1 and 2 significantly suppressed the proliferation and migration of gastric adenocarcinoma cells (SGC-7901 and MGC-803) dose-dependently. These findings demonstrate the potential of 1 and 2 as favorable candidates for further anticancer drug development.