Issue 20, 2025

Hydrogen-bonding-controlled stereospecific synthesis of Z-enamides

Abstract

In this study, a series of Z-enamide compounds were synthesized from α-amino ketones and alkynyl esters. Using triethylamine as the base catalyst, the reaction proceeded smoothly at room temperature to yield stereospecific products with high yields. Two X-ray crystals of products confirmed the crucial role of hydrogen bonding in stereospecificity.

Graphical abstract: Hydrogen-bonding-controlled stereospecific synthesis of Z-enamides

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Article information

Article type
Communication
Submitted
25 Feb 2025
Accepted
16 Apr 2025
First published
23 Apr 2025

Org. Biomol. Chem., 2025,23, 4884-4887

Hydrogen-bonding-controlled stereospecific synthesis of Z-enamides

X. Zhang, X. Lu, Y. Zou, J. Lang, Y. Wang and G. Zhao, Org. Biomol. Chem., 2025, 23, 4884 DOI: 10.1039/D5OB00333D

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