Fluorohydrins and where to find them: recent asymmetric syntheses of β-fluoro alcohols and their derivatives

Abstract

Fluorohydrins – or β-fluorinated alcohols – and their fluorinated group derivatives are a biologically relevant class of compounds, with applications ranging from PET tracers to cancer therapeutics. Recent efforts have unlocked asymmetric access to these related motifs through reactions of carbonyls, alkenes, organoboranes, and epoxides or transformations such as cyclizations or ring expansions. The present work provides an overview of synthetic approaches to various fluorohydrins that have been explored in the past decade, as well as selected examples of these syntheses applied to medicinal chemistry.