Synthesis of dihydropyrimidinones via urea-based multicomponent reactions

Abstract

Multicomponent reactions (MCRs) have emerged as powerful tools in organic chemistry, enabling the rapid and efficient assembly of complex molecular architectures. Urea-based multicomponent reactions have gained significant attention due to their versatility and broad applicability. In this review, we highlight recent developments in this area, with a focus on dihydropyrimidinones, and provide an in-depth analysis of the diverse synthetic pathways and applications of urea-based MCRs, shedding light on their fundamental mechanisms, reaction conditions, and potential for green and sustainable synthesis.