Issue 21, 2025

Synthesis of dihydropyrimidinones via urea-based multicomponent reactions

Abstract

Multicomponent reactions (MCRs) have emerged as powerful tools in organic chemistry, enabling the rapid and efficient assembly of complex molecular architectures. Urea-based multicomponent reactions have gained significant attention due to their versatility and broad applicability. In this review, we highlight recent developments in this area, with a focus on dihydropyrimidinones, and provide an in-depth analysis of the diverse synthetic pathways and applications of urea-based MCRs, shedding light on their fundamental mechanisms, reaction conditions, and potential for green and sustainable synthesis.

Graphical abstract: Synthesis of dihydropyrimidinones via urea-based multicomponent reactions

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Article information

Article type
Review Article
Submitted
31 Jan 2025
Accepted
28 Apr 2025
First published
29 Apr 2025

Org. Biomol. Chem., 2025,23, 5064-5080

Synthesis of dihydropyrimidinones via urea-based multicomponent reactions

A. Mandal, P. Ghosh and S. Das, Org. Biomol. Chem., 2025, 23, 5064 DOI: 10.1039/D5OB00180C

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