Göran Schulz, Julia Maletz, Pascal Janisch, Stefan Moczarski and Dmytro Ostrovskyi
Org. Biomol. Chem., 2025,23, 2726-2730
DOI:
10.1039/D5OB00132C,
Paper
A scalable and diastereoselective synthesis of four icafolin–methyl plant metabolites bearing a 4-hydroxy-2-isoxazoline scaffold is described. The key to success was a practical cyclocondensation of 3,5-difluoronitromethane with α-formylbutyrolactone and a multigram-scale Grieco dehydration protocol, performed in continuous flow.
