Ruthenium(ii)-catalyzed synthesis of poly-substituted furans via intermolecular oxidative annulation of 3-(phenylethynyl) oxazolidin-2-ones

Abstract

This study presents a new method for the synthesis of poly-substituted furans by an oxidative annulation reaction of ynamides in the presence of Ru(II) as a catalyst, copper(II) triflate Cu(OTf)₂ as an oxidant, and cesium carbonate (Cs₂CO₃) as a base. The reaction shows broad substrate scope and compatibility with readily available starting materials, with yields ranging from good to excellent.