Tunable base-controlled chemoselective synthesis of trifluoromethyl-containing N-substituted benzimidazole-2-thiones and monofluorinated 4H-benzo[4,5]imidazo[2,1-b][1,3]thiazine

Abstract

A highly efficient base-controlled synthesis of N-β-trifluoromethyl-substituted 2H-benzo[d]imidazole-2-thiones and 2-fluoro-4H-benzo[4,5]imidazo[2,1-b][1,3]thiazines via hydroamination or defluorinative cyclizations of α-(trifluoromethyl)styrenes with 2-mercaptobenzimidazole was developed.