Metal-free hydrodifunctionalization of enaminones for the synthesis of ketomethylene-functionalized phosphoryl alcohols

Abstract

Reported here is a set of three-component reactions of enaminones with diaryl phosphine oxides and water for the synthesis of ketomethylene-functionalized gem-phosphoryl alcohols via enaminone hydrodifunctionalization, enabling the cascade construction of new C–P, C–O and C–H bonds. The method displays notable advantages including mild metal-free conditions, a broad application scope and being free of the need to carry out chromatographic purification.