Mechanochemically facilitated silver-catalyzed direct H/D exchange on heteroarenes

Abstract

Despite recent advances in H/D exchange, the effective deuteration of polyarenes remains challenging, due to their insolubility and hydrophobicity. This study presents a concept proofing of a mechanochemically facilitated direct H/D exchange. The silver-catalyzed deuteration of heteroarenes was promoted smoothly within 99 minutes of grinding, with heavy water as the deuterium source.