Visible-Light-Induced Radical Trifluoromethylation/Cyclization of N-Arylacrylamides with Trifluoromethyl Phenyl Sulfone
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Shuaijun Han , Shengnan Zhao , Liyan Dong , Yang Geng , Xin Lu , Bing Liu and Kaige Shi
First published on 29th October 2025
Abstract
An efficient method for the visible-light-induced radical trifluoromethylation/cyclization of N-arylacrylamides with trifluoromethyl phenyl sulfone has been developed. This transformation benefits from mild conditions, readily available CF3 radical precursors and wide substrate scope. In addition, this protocol not only affords a new synthetic application of trifluoromethyl phenyl sulfone, but also offers a new route to generate trifluoromethyl radical.