Synthesis of trifluoromethyl-functionalized benzo[de][1,8]naphthyridines via Rh(iii)-catalyzed two-fold C–H activation of benzamidine hydrochlorides and annulation with CF3-imidoyl sulfoxonium ylides

Abstract

A Rh(III)-catalyzed two-fold C–H activation of benzamidine hydrochlorides and cascade annulation with CF₃-imidoyl sulfoxonium ylides (TFISYs) has been disclosed. The transformation enables the formation of four new chemical bonds in a one-pot reaction, providing a powerful and straightforward pathway for the construction of trifluoromethyl-functionalized benzo[de][1,8]naphthyridines in moderate to excellent yields.