Injectable bioactive wood-collagen nanocomposites for enhanced skin regeneration

Abstract

Skin aging is a pervasive concern that profoundly impacts human well-being and quality of life, while also heightening the risk of skin diseases, including skin cancer. Implants offer a promising treatment option for skin aging, but current implants degrade quickly and have low bioactivity, resulting in reduced therapeutic efficacy. This study introduces a novel injectable, long-lasting, highly bioactive collagen-coated nanoparticle implant for skin rejuvenation. The nanowood, produced through delignification, air-assisted superfine grinding, and sieving, demonstrates excellent injectability. The collagen-coated nanowood implant exhibits remarkable biocompatibility and bioactivity, significantly enhancing the proliferation, adhesion, and migration of human foreskin fibroblast-1 cells. In photoaged mouse skin models, the implant substantially improves dermal density and skin elasticity, creating an environment conducive to fibroblast activity and collagen regeneration. Furthermore, the implant shows excellent biosafety, with no pyrogenic or hemolytic risks. Injectable nanowood implants are a promising approach to skin regeneration with important potential applications in dermatology and tissue engineering.