Multifunctional Au@ZIF-8/Fe nanomedicines for ferroptosis-induced therapy in triple-negative breast cancer

Baicheng Liao; Xiuli Zhang; Gen Li; Wenhui Yang; Xiaoli Chen; Nan Yu; Liyong Chen; Xuefu Hu

doi:10.1039/D5NJ00297D

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Multifunctional Au@ZIF-8/Fe nanomedicines for ferroptosis-induced therapy in triple-negative breast cancer†

Baicheng Liao,‡^a Xiuli Zhang,‡^a Gen Li,^a Wenhui Yang,^a Xiaoli Chen,^a Nan Yu,*^c Liyong Chen

*^ab and Xuefu Hu*^a

Author affiliations

* Corresponding authors

^a Department of Pharmaceutical Engineering, Bengbu Medical University, Bengbu, China
E-mail: lychen@bbmc.edu.cn

^b Anhui Provincial Key Laboratory of Tumor Evolution and Intelligent Diagnosis and Treatment, Bengbu Medical University, Bengbu, China

^c Anhui Laboratory of Molecule-Based Materials, College of Chemistry and Materials Science, Anhui Normal University, Wuhu, China
E-mail: yn2009@ahnu.edu.cn

Abstract

Au@ZIF-8/Fe nanomedicine induces ferroptosis in 4T1 tumor cells by enhancing ROS generation and LPO through the Fenton reaction. Its disruption of the GPX4 pathway underscores its potential as an effective anticancer therapy.

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Article information

DOI: https://doi.org/10.1039/D5NJ00297D
Article type: Communication
Submitted: 22 Jan 2025
Accepted: 08 Apr 2025
First published: 11 Apr 2025

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New J. Chem., 2025,49, 7297-7301

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Multifunctional Au@ZIF-8/Fe nanomedicines for ferroptosis-induced therapy in triple-negative breast cancer

B. Liao, X. Zhang, G. Li, W. Yang, X. Chen, N. Yu, L. Chen and X. Hu, New J. Chem., 2025, 49, 7297 DOI: 10.1039/D5NJ00297D

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New Journal of Chemistry

Multifunctional Au@ZIF-8/Fe nanomedicines for ferroptosis-induced therapy in triple-negative breast cancer†

Abstract

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Article information

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Multifunctional Au@ZIF-8/Fe nanomedicines for ferroptosis-induced therapy in triple-negative breast cancer

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