Open Access Article
This Open Access Article is licensed under a Creative Commons Attribution 3.0 Unported Licence
Correction: Switchable nanoparticle for programmed gene-chem delivery with enhanced neuronal recovery and CT imaging for neurodegenerative disease treatment
Linying
Liu
ab,
Yan
Li
a,
Ruiyuan
Liu
ab,
Qi
Shen
a,
Yanhui
Li
a,
Zhuyan
Shi
ab,
Jie
Shen
ab,
Weihong
Ji
ab and
Xin
Zhang
*a
aState Key Laboratory of Biochemical Engineering, Institute of Process Engineering, Chinese Academy of Sciences, Beijing 100190, P. R. China. E-mail: xzhang@ipe.ac.cn
bUniversity of Chinese Academy of Sciences, No. 19(A) Yuquan Road, Shijingshan District, Beijing 100049, P. R. China
First published on 14th July 2025
Abstract
Correction for ‘Switchable nanoparticle for programmed gene-chem delivery with enhanced neuronal recovery and CT imaging for neurodegenerative disease treatment’ by Linying Liu et al., Mater. Horiz., 2019, 6, 1923–1929, https://doi.org/10.1039/C9MH00482C.
The authors have provided the following clarification of the MTPT administration experimental protocol that was used, in order to provide sufficient detail to enable a skilled researcher to repeat the experiments:
In vivo therapy of Parkinson's disease model mice. Four groups of C57BL/6 mice (8 weeks) were intraperitoneally injected with MPTP (30 mg kg−1) for 7 consecutive days. Afterwards, open field tests and pole tests were utilized to investigate the change in exercise. In detail, open field testing was conducted on the third day after a two-day open field test adaptation. Another one-day pole test adaptation was then carried out, and the pole test was carried out the next day. Two days were given to allow the mice to rest. The behavioral experiment including adaptation, and formal testing, took a total of 7 days. Three groups of MPTP-induced PD mice were then treated with different formulations of NPs (III, IV, V) at a dose of 1 mg kg−1 siSNCA by intravenous injection every three days for 10 times. One group of MPTP-induced PD mice (II) were treated with the same volume of saline. The wild mice were used as a control. After treatment, open field tests and pole tests were performed to evaluate the therapeutic efficacy. For pole tests, we placed the mice upright on a 50 cm high pole and recorded the time they took for the entire journey to assess the movement coordination of the mice. The journey time was from the start until all the limbs of the mouse landed. For open field tests, we placed the mice in the open field instrument and recorded their track of motion.
The Royal Society of Chemistry apologises for these errors and any consequent inconvenience to authors and readers.
| This journal is © The Royal Society of Chemistry 2025 |