Recent developments in high-pressure promoted cycloaddition reactions: experimental and theoretical perspectives

Abstract

Cycloadditions are fundamental transformations in the synthetic chemist's toolkit, though they can sometimes lead to disappointing results due to steric or electronic constraints. High-pressure conditions offer an effective alternative strategy for promoting these difficult cases, often reducing or eliminating the need for chemical catalysts. This review highlights recent advances in high-pressure-mediated cycloadditions, from both experimental and theoretical perspectives. The compilation emphasizes how high-pressure techniques are particularly well-suited to these transformations, enhancing efficiency while promoting greener, more sustainable chemistry.