From the journal:

Chemical Communications

Base-promoted cascade annulation and annulation/carboxylation of α-enolizable phosphoryl substituted ynones and isatins with CO2

Alexander E. Savoskin,a   Andrey N. Efremov,a   Arina V. Murashkina,a   Victoriya E. Gontcharenko,bc   Andrei V. Bogdanov,d   Alexander Yu. Mitrofanov ORCID logo *a  and  Irina P. Beletskaya ORCID logo a  

* Corresponding authors

a Lomonosov Moscow State University, Department of Chemistry, Leninskie Gory, GSP-1, Moscow 119991, Russia
E-mail: oksazol@gmail.com

b Faculty of Chemistry, National Research University Higher School of Economics, 20 Miasnitskaya Street, Moscow 101000, Russia

c P.N. Lebedev Physical Institute of the Russian Academy of Sciences, 53, Leninsky Prospect, Moscow 119991, Russia

d Arbuzov Institute of Organic and Physical Chemistry, FRC Kazan Scientific Center, Russian Academy of Sciences, Akad. Arbuzov St. 8, Kazan 420088, Russia

Abstract

A base-catalyzed cascade reaction of isatins and α-enolizable phosphoryl substituted ynones has been developed leading to spiroindolin-2-ones. The reaction is an anion-anionic domino process, where an unprecedented interception of the vinyl anion by the intermediate CO2 was achieved to obtain spiroindolin-2-ones bearing a phosphonoacetate fragment.

Graphical abstract: Base-promoted cascade annulation and annulation/carboxylation of α-enolizable phosphoryl substituted ynones and isatins with CO2

About
Cited by
Related
Download options Please wait...

Supplementary files

Article information

DOI
https://doi.org/10.1039/D5CC04158A
Article type
Communication
Submitted
22 Jul 2025
Accepted
08 Sep 2025
First published
09 Sep 2025

Chem. Commun., 2025, Advance Article

Permissions

Request permissions

Base-promoted cascade annulation and annulation/carboxylation of α-enolizable phosphoryl substituted ynones and isatins with CO2

A. E. Savoskin, A. N. Efremov, A. V. Murashkina, V. E. Gontcharenko, A. V. Bogdanov, A. Yu. Mitrofanov and I. P. Beletskaya, Chem. Commun., 2025, Advance Article , DOI: 10.1039/D5CC04158A

To request permission to reproduce material from this article, please go to the Copyright Clearance Center request page.

If you are an author contributing to an RSC publication, you do not need to request permission provided correct acknowledgement is given.

If you are the author of this article, you do not need to request permission to reproduce figures and diagrams provided correct acknowledgement is given. If you want to reproduce the whole article in a third-party publication (excluding your thesis/dissertation for which permission is not required) please go to the Copyright Clearance Center request page.

Read more about how to correctly acknowledge RSC content.

Social activity

Spotlight

Advertisements