Accessing diverse fluorinated organic molecules by fluoro-functionalization reactions of enaminones

Abstract

Fluorinated organic molecules constitute compounds with well-known and potential applications in the chemical industry and many related areas. Accordingly, the synthesis of fluorinated compounds has emerged as one of the central tasks of modern organic synthesis. As valuable and versatile synthons, enaminones have displayed amazingly broad application in the designation of novel organic reactions. Notably, the reactions of enaminones with fluorine reagents for the synthesis of fluoro-functionalized products have undergone important advances, providing useful and practical access to various fluorinated compounds. In this review, we summarize for the first time the state of the art in the fluoro-functionalized reactions of enaminones for the synthesis of fluoro-functionalized molecules, in the category of key transformation modes of enaminones, including C–F bond functionalization, C–C bond functionalization, and cascade annulation, covering works reported since 2017.

Graphical abstract: Accessing diverse fluorinated organic molecules by fluoro-functionalization reactions of enaminones

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Article information

Article type
Feature Article
Submitted
16 Jul 2025
Accepted
12 Aug 2025
First published
13 Aug 2025

Chem. Commun., 2025, Advance Article

Accessing diverse fluorinated organic molecules by fluoro-functionalization reactions of enaminones

B. Zhao, J. Liu and J. Wan, Chem. Commun., 2025, Advance Article , DOI: 10.1039/D5CC04020E

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