Issue 89, 2025
From the journal:

Chemical Communications

One-step naked-eye fluorescence detection of viruses using quantum dot-magnetic beads coupled with CRISPR/Cas12a

Ai-Xin Ma,a   Qing Zhang,a   Ming-Yu Zhang,a   Shu-Lin Liu, ORCID logo a   Zhi-Gang Wang ORCID logo a  and  Dai-Wen Pang ORCID logo *a  

* Corresponding authors

a State Key Laboratory of Medicinal Chemical Biology, Tianjin Key Laboratory of Biosensing and Molecular Recognition, Research Center for Analytical Sciences, College of Chemistry, and School of Medicine, Nankai University, Tianjin 300071, P. R. China
E-mail: dwpang@whu.edu.cn

Abstract

This work constructs quantum dot-magnetic beads coupled with CRISPR/Cas12a for naked-eye detection of herpes simplex virus. The system integrates the high brightness of quantum dots and trans-cleavage activity of Cas12a, enabling rapid, simple, and accurate viral detection.

Graphical abstract: One-step naked-eye fluorescence detection of viruses using quantum dot-magnetic beads coupled with CRISPR/Cas12a

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Article information

DOI
https://doi.org/10.1039/D5CC03645C
Article type
Communication
Submitted
28 Jun 2025
Accepted
03 Oct 2025
First published
03 Oct 2025

Chem. Commun., 2025,61, 17432-17435

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One-step naked-eye fluorescence detection of viruses using quantum dot-magnetic beads coupled with CRISPR/Cas12a

A. Ma, Q. Zhang, M. Zhang, S. Liu, Z. Wang and D. Pang, Chem. Commun., 2025, 61, 17432 DOI: 10.1039/D5CC03645C

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