A J-aggregating cyanine-based NIR-II optical sensor for DNA aptamer-mediated detection and imaging of quinine

Gaowei Deng; Chaobang Zhang; Jiawei Chen; Fang Zeng; Shuizhu Wu

doi:10.1039/D5CC03180J

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A J-aggregating cyanine-based NIR-II optical sensor for DNA aptamer-mediated detection and imaging of quinine

Gaowei Deng,

†^a Chaobang Zhang,†^a Jiawei Chen,^a Fang Zeng

*^a and Shuizhu Wu

*^a

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* Corresponding authors

^a State Key Laboratory of Luminescent Materials and Devices, Guangdong Provincial Key Laboratory of Luminescence from Molecular Aggregates, School of Materials Science and Engineering, South China University of Technology, Guangzhou 510640, China
E-mail: mcfzeng@scut.edu.cn, shzhwu@scut.edu.cn

Abstract

We report a dye-displacement assay for quinine detection integrating a DNA aptamer with a J-aggregating NIR-II cyanine dye. This platform achieves sensitive, selective, and label-free NIR-II colorimetric and fluorescence sensing, with a fluorescence-based detection limit as low as 0.014 μM in urine solution, and enables NIR-II fluorescence imaging.

This article is part of the themed collection: Aggregation-Induced Emission

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DOI: https://doi.org/10.1039/D5CC03180J
Article type: Communication
Submitted: 05 Jun 2025
Accepted: 11 Aug 2025
First published: 13 Aug 2025

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Chem. Commun., 2025, Advance Article

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A J-aggregating cyanine-based NIR-II optical sensor for DNA aptamer-mediated detection and imaging of quinine

G. Deng, C. Zhang, J. Chen, F. Zeng and S. Wu, Chem. Commun., 2025, Advance Article , DOI: 10.1039/D5CC03180J

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Chemical Communications

A J-aggregating cyanine-based NIR-II optical sensor for DNA aptamer-mediated detection and imaging of quinine

Abstract

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A J-aggregating cyanine-based NIR-II optical sensor for DNA aptamer-mediated detection and imaging of quinine

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