Construction of dibenzo[1,4]oxazocines via palladium-catalysed arylalkylation of allenamides

Abstract

Efficient access to eight-membered N-heterocycles through a palladium-catalysed dicarbofunctionalization of allenamides has been developed. The allyl-palladium intermediate, which was generated via an intramolecular allene insertion reaction, underwent allylic substitution with carbon-anion nucleophiles to form dibenzo[1,4]oxazocine derivatives with broad functional group tolerance under mild reaction conditions.