From the journal:

Chemical Communications

Unsymmetric thieno-phospha-rhodamines: a new class of near-infrared fluorescent probes for stimuli-responsive organelle imaging

Sibo Ma,a   Yuichi Asada,a   Shigehiro Yamaguchi ORCID logo *ab  and  Masayasu Taki ORCID logo *bcd  

* Corresponding authors

a Department of Chemistry, Graduate School of Science and Integrated Research Consortium on Chemical Sciences (IRCCS), Nagoya University, Furo, Chikusa, Nagoya 464-8602, Japan
E-mail: yamaguchi@chem.nagoya-u.ac.jp

b Institute of Transformative Bio-Molecules (WPI-ITbM), Nagoya University, Furo, Chikusa, Nagoya 464-8601, Japan
E-mail: taki.masayasu.s8@f.gifu-u.ac.jp

c Institute for Glyco-core Research (iGCORE), Gifu University, 1-1 Yanagido, Gifu 501-1193, Japan

d Department of Chemistry and Biomolecular Science, Faculty of Engineering, Gifu University, 1-1 Yanagido, Gifu 501-1193, Japan

Abstract

We report thieno-phospha-rhodamine (TPR) dyes as a novel class of near-infrared (NIR)-emissive fluorophores featuring an unsymmetric π-skeleton. TPR dyes exhibit emission maxima near 800 nm, large Stokes shifts, and excellent photostability. Notably, TPR-Et displays dual organelle localization that dynamically responds to changes in mitochondrial membrane potential and lysosomal pH.

Graphical abstract: Unsymmetric thieno-phospha-rhodamines: a new class of near-infrared fluorescent probes for stimuli-responsive organelle imaging

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Article information

DOI
https://doi.org/10.1039/D5CC03133H
Article type
Communication
Submitted
03 Jun 2025
Accepted
12 Aug 2025
First published
18 Aug 2025

Chem. Commun., 2025, Advance Article

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Unsymmetric thieno-phospha-rhodamines: a new class of near-infrared fluorescent probes for stimuli-responsive organelle imaging

S. Ma, Y. Asada, S. Yamaguchi and M. Taki, Chem. Commun., 2025, Advance Article , DOI: 10.1039/D5CC03133H

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