From the journal:

Chemical Communications

Total synthesis and algaecidal activity of questiomycins against harmful bloom forming dinoflagellates†

Shuxin Yang,a   Niraj Aryal,b   Siti Nur Qamarina Binti Azmi,a   Yanfei Wang,c   Laura Burchill, ORCID logo a   Laurel E. Meke,b   Bryndan P. Durham ORCID logo *b  and  Spencer J. Williams ORCID logo *a  

* Corresponding authors

a School of Chemistry and Bio21 Molecular Science and Biotechnology Institute, University of Melbourne, Parkville, Victoria 3010, Australia
E-mail: sjwill@unimelb.edu.au

b Department of Biology and Genetics Institute, University of Florida, Gainesville, Florida, USA
E-mail: b.durham@ufl.edu

c Earth, Ocean, and Environment, University of Delaware, Lewes, Delaware, USA

Abstract

We report the total synthesis of questiomycins A, C–E and analogues, and their algaecidal activity against three harmful bloom- and toxin-forming algae: Karenia brevis, Prorocentrum cordatum, and Amphidinium carterae. Structure–activity relationship studies revealed potent derivatives with distinct modes of action, signalling their potential as targeted agents for harmful algal bloom control.

Graphical abstract: Total synthesis and algaecidal activity of questiomycins against harmful bloom forming dinoflagellates

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Article information

DOI
https://doi.org/10.1039/D5CC02853A
Article type
Communication
Submitted
20 May 2025
Accepted
19 Jun 2025
First published
19 Jun 2025

Chem. Commun., 2025, Advance Article

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Total synthesis and algaecidal activity of questiomycins against harmful bloom forming dinoflagellates

S. Yang, N. Aryal, S. N. Q. B. Azmi, Y. Wang, L. Burchill, L. E. Meke, B. P. Durham and S. J. Williams, Chem. Commun., 2025, Advance Article , DOI: 10.1039/D5CC02853A

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