KOtBu-mediated annulation for the pot-economical synthesis of quinazolinobenzoxazepines

Soumya Jyoti Basak; Jyotirmayee Dash

doi:10.1039/D5CC02401C

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KO^tBu-mediated annulation for the pot-economical synthesis of quinazolinobenzoxazepines†

Soumya Jyoti Basak^a and Jyotirmayee Dash

*^a

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* Corresponding authors

^a School of Chemical Sciences, Indian Association for the Cultivation of Science, Jadavpur, Kolkata-700032, India
E-mail: ocjd@iacs.res.in

Abstract

A novel and cost-effective KO^tBu-mediated protocol has been developed for synthesizing quinazolinobenzoxazepines from 2-aminobenzonitriles and 2-(2-bromoethoxy)benzaldehydes. This transformation proceeds via a cascade pathway and affords products in moderate to good yields with broad substrate scope and excellent functional group tolerance.

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Article information

DOI: https://doi.org/10.1039/D5CC02401C
Article type: Communication
Submitted: 29 Apr 2025
Accepted: 17 Jul 2025
First published: 22 Jul 2025

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Chem. Commun., 2025, Advance Article

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KO^tBu-mediated annulation for the pot-economical synthesis of quinazolinobenzoxazepines

S. J. Basak and J. Dash, Chem. Commun., 2025, Advance Article , DOI: 10.1039/D5CC02401C

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