Issue 61, 2025

Acid-triggered cascade cyclization pathways of enynes: A rapid access to fused polycyclic products

Abstract

Herein, we present a novel acid-triggered cyclization of enyne biaryl systems, producing discrete phenanthrene-fused polycyclic (tri-/tetra-/penta-cyclic) products, depending upon the stereoelectronic effects of substituents. Notably, the accomplished pentacyclic structures constitute the complete core structures of natural products, namely clostrubin and borolithochromes, offering a rapid synthetic route. In addition, the absorption and emission properties of the synthesized products have been studied.

Graphical abstract: Acid-triggered cascade cyclization pathways of enynes: A rapid access to fused polycyclic products

Supplementary files

Article information

Article type
Communication
Submitted
16 Apr 2025
Accepted
18 Jun 2025
First published
23 Jun 2025

Chem. Commun., 2025,61, 11457-11460

Acid-triggered cascade cyclization pathways of enynes: A rapid access to fused polycyclic products

K. Goel, D. Shree V and G. Satyanarayana, Chem. Commun., 2025, 61, 11457 DOI: 10.1039/D5CC02143J

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