Enabling an ultra-specific lysosomal polarity fluorescence response via intramolecular π–π stacking-mediated conformational locking

Jiaqi Su; Chunbai Xiang; Jiao Lu; Binhao Li; Yuxuan Liu; Chuanhao Liu; Shiyi Tian; Wenxiao Deng; Yuchang Tan; Yanju Luo; Yan Huang; Yanfei Tan; Zhiyun Lu

doi:10.1039/D5CC01905B

Enabling an ultra-specific lysosomal polarity fluorescence response via intramolecular π–π stacking-mediated conformational locking†

Jiaqi Su,‡^a Chunbai Xiang,‡^a Jiao Lu,^b Binhao Li,^a Yuxuan Liu,^a Chuanhao Liu,

^c Shiyi Tian,^a Wenxiao Deng,^a Yuchang Tan,^a Yanju Luo,

^c Yan Huang,

^a Yanfei Tan

*^b and Zhiyun Lu

*^a

Author affiliations

* Corresponding authors

^a Key Laboratory of Green Chemistry and Technology (Ministry of Education), College of Chemistry, Sichuan University, Chengdu 610064, P. R. China
E-mail: luzhiyun@scu.edu.cn

^b National Engineering Research Center for Biomaterials and College of Biomedical Engineering, Sichuan University, Chengdu, P. R. China
E-mail: tanyf@scu.edu.cn

^c Analytical & Testing Center, Sichuan University, Chengdu 610064, P. R. China

Abstract

Designing ultra-specific polar fluorescent probes through the strategy of intramolecular π–π interactions was reported. Based on this strategy, a high-performance lysosomal polarity probe, named P-DOTPA, was developed. It exhibits high specificity, ultra-high sensitivity, near-infrared emission, and the ability to generate superoxide radicals (O₂⁻˙) under irradiation.

Chemical Communications

Enabling an ultra-specific lysosomal polarity fluorescence response via intramolecular π–π stacking-mediated conformational locking†

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Enabling an ultra-specific lysosomal polarity fluorescence response via intramolecular π–π stacking-mediated conformational locking

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