Deuteration of organic compounds by electrolysis of glucose-heavy water using a graphene oxide membrane reactor

Le Mai Hong Tham; Imam Sahroni; Ghina Kifayah Putri; Taiga Kodama; Muhammad Fadil; Takeru Nakahara; Ami Takase; Muhammad Sohail Ahmad; Armando T. Quitain; Yusuke Inomata; Prasert Reubroycharoen; Tetsuya Kida

doi:10.1039/D5CC01646K

Deuteration of organic compounds by electrolysis of glucose-heavy water using a graphene oxide membrane reactor†

Le Mai Hong Tham,‡^a Imam Sahroni,

‡^bc Ghina Kifayah Putri,^b Taiga Kodama,^b Muhammad Fadil,^b Takeru Nakahara,^b Ami Takase,^b Muhammad Sohail Ahmad,

^de Armando T. Quitain,

^f Yusuke Inomata,^b Prasert Reubroycharoen*^a and Tetsuya Kida

*^bde

Author affiliations

* Corresponding authors

^a Center of Excellence in Catalysis for Bioenergy and Renewable Chemicals (CBRC), Department of Chemical Technology, Faculty of Science, Chulalongkorn University, Bangkok 10330, Thailand
E-mail: prasert.r@chula.ac.th

^b Graduate School of Science and Technology, Department of Applied Chemistry and Biochemistry, Faculty of Advanced Science and Technology, Kumamoto University, Kumamoto, Japan
E-mail: tetsuya@kumamoto-u.ac.jp

^c Department of Chemistry, Faculty of Mathematics and Natural Sciences, Universitas Islam Indonesia, Sleman, Yogyakarta, Indonesia

^d Institute of Industrial Nanomaterials (IINa), Kumamoto University, Kumamoto 860-8555, Japan

^e International Research Organization for Advanced Science and Technology (IROAST), Kumamoto University, Kumamoto 860-8555, Japan

^f Center for International Education, Kumamoto University, Kumamoto 860-8555, Japan

Abstract

This study explores the cost-effective synthesis of deuterium-labelled compounds via electrolysis of glucose-heavy water (D₂O) employing a proton-conducting graphene oxide membrane (GOM) with Pt/C and IrO₂/Al₂O₃. C(sp³)–H bonds of mono, double, and triple methyl groups in aromatic compounds were successfully deuterated with high deuterium incorporation (%) and excellent yield (%).

Chemical Communications

Deuteration of organic compounds by electrolysis of glucose-heavy water using a graphene oxide membrane reactor†

Abstract

Supplementary files

Article information

Download Citation

Permissions

Deuteration of organic compounds by electrolysis of glucose-heavy water using a graphene oxide membrane reactor

Social activity

Search articles by author

Spotlight

Advertisements