Dual-nickel/photoredox-catalyzed acylation of spiro-dihydroquinazolinones with carboxylic acids via an aromatization-driven deconstructive strategy

Abstract

Dual-nickel/photoredox-catalyzed aromatization-mediated deconstruction and acylation of spiro-dihydroquinazolinones with carboxylic acids serving as acyl electrophiles is described. A series of synthetical ketone scaffolds with functional group tolerance could be obtained under mild conditions. A radical pathway involving an N-centered radical inducing β-scission to form a C-centered radical is proposed for these transformations.