A novel peptide targeting PD-1: implications for protein–protein interaction studies and immunotherapy

Abstract

Chemical ligand binding to PD-1 is a powerful approach for studying protein–protein interactions and advancing immunotherapy. In this study, we introduce a novel II peptide with strong binding affinity for PD-1. Molecular docking analysis reveals key interactions between the II peptide and PD-1, supporting inhibition ELISA data and indicating that the II peptide overlaps with the PD-1/PD-L1 interaction interface.