Issue 40, 2025
From the journal:

Chemical Communications

A membrane-penetrative COF-based nanoplatform for intracellular bacterial pathogen eradication across diverse niches†

Yuxi Fang,‡ab   Jiadai Yi,‡ab   Huan Wang, ORCID logo *a   Yanjie Zhang,ab   Yue Sun,ab   Jinsong Ren ORCID logo *ab  and  Xiaogang Qu ORCID logo *ab  

* Corresponding authors

a State Key Laboratory of Rare Earth Resource Utilization and Laboratory of Chemical Biology, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, Changchun, Jilin 130022, P. R. China
E-mail: huanwang@ciac.ac.cn, jren@ciac.ac.cn, xqu@ciac.ac.cn

b School of Applied Chemistry and Engineering, University of Science and Technology of China, Hefei, Anhui 230026, P. R. China

Abstract

A COF-based therapeutic nanoplatform has been developed that can be transported to intracellular bacteria-located regions in the host cells, where ultrasound irradiation triggered ROS generation, membrane-penetrative NO release, and the production of highly reactive peroxynitrite (ONOO−), enabling effective bacteria eradication across diverse niches.

Graphical abstract: A membrane-penetrative COF-based nanoplatform for intracellular bacterial pathogen eradication across diverse niches

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Article information

DOI
https://doi.org/10.1039/D5CC01091H
Article type
Communication
Submitted
28 Feb 2025
Accepted
13 Apr 2025
First published
16 Apr 2025

Chem. Commun., 2025,61, 7289-7292

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A membrane-penetrative COF-based nanoplatform for intracellular bacterial pathogen eradication across diverse niches

Y. Fang, J. Yi, H. Wang, Y. Zhang, Y. Sun, J. Ren and X. Qu, Chem. Commun., 2025, 61, 7289 DOI: 10.1039/D5CC01091H

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